globe
  1. Core Materials 3 items
    Either book is recommended for purchase. Students with an interest in recreational drug use may prefer Meyer and Quenzer (2013), Julien (2011) is more relevant to anyone interested in clinical drug use. When chapters from both books are set as 'core reading' you do not need to read both as they cover very similar material
    1. Julien's primer of drug action - Claire D. Advokat, Joseph E. Comaty, Robert M. Julien 2014

      Book Core

    2. Psychopharmacology: drugs, the brain, and behavior - Jerrold S. Meyer, Linda F. Quenzer c2013

      Book Core

    3. Psychopharmacology: drugs, the brain, and behavior - Jerrold S. Meyer 2019

      Book Core

  2. Week 1: Introduction to the module and some basic biology 2 items
    1. Core Reading 1 item
      1. Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the brain and behaviour. Sunderland: Sinauer Associates. Chapter 1, p.3-36.

         

        Julien, R.M. (2011) A Primer of Drug Action 12th Ed. New York: Worth Publishers Chapter 1 'Pharmacokinetics: How drugs are handled by the body.' p 3-34. *

        Julien, R.M. (2011) A Primer of Drug Action 12th Ed. New York: Worth Publishers

        Chapter 3 'The Neuron, synaptic transmission and neurotransmitters' p. 60-72 only

        The latter half (p.73-88) of this chapter discusses individual neurotransmitters. We will cover this material later in the unit, when we discuss drugs that affect acetylcholine, serotonin, dopamine etc. 

    2. Week 2: Neurotransmission and Drug Effects 1 item
      1. Core Reading 1 item
        1. Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the brain and behaviour. Sunderland: Sinauer Associates. Chapter 2, p42-56 (the last section of this chapter provides an overview of struture and function of the nervous system. It would be useful to review this chapter but it is not essential reading) and Chapter 3 p.78-92 (You do not need to read the last section of this chapter, on hormones and the endocrine system, for this module). 

           

          Julien, R.M. (2011) A Primer of Drug Action 12th Ed. New York:Worth Publishers: Chapter 2 'Pharmacodynamics. How drugs act' p. 36-59

          Julien, R.M. (2011) A Primer of Drug Action 12th Ed. New York: Worth Publishers

          Chapter 3 'The Neuron, synaptic transmission and neurotransmitters' p. 60-72 only

          The latter half (p.73-88) of this chapter discusses individual neurotransmitters. We will cover this material later in the unit, when we discuss drugs that affect serotonin, noradrenalin, acetylcholine etc.

  3. Week 3: Research in Psychopharmacology; Methods, ethics and the use of animals 4 items
    1. Core Reading 4 items
      1. Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the brain and behaviour. Sunderland: Sinauer Associates. Chapter 4, page 107-120 only.

      2. 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice - José Manuel Trigo, Thibault Renoir, Laurence Lanfumey, Michel Hamon 2007-9

        Article Core You MUST read this paper before coming to class in week 3. We will spend class time helping you to read and understand this kind of journal article.

      3. Rodent models in depression research: Classical strategies and new directions - Daniela D. Pollak, Carlos E. Rey, Francisco J. Monje 06/05/2010

        Article 

  4. Week 4: Recreational and abusive use of drugs 14 items
    1. Core Reading 9 items
      1. Julien, R.M. (2011) A Primer of Drug Action 12th Ed. New York: Worth Publishers Chapter 17 'Topics in Drug Abuse' p 564-588

         

        Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the brain and behaviour. Sunderland: Sinauer Associates Chapter 9, p.228-237, for historical trends in drug use and drug addiction in general, Chapter 10, p.266-284 for more information on alcohol, Chapter 12, p. 340-359 for more information on cocaine and Chapter 15, p430-442 for hallucinogens. 

      2. Harms associated with psychoactive substances: findings of the UK National Drug Survey - C. J. Morgan, L. Muetzelfeldt, M. Muetzelfeldt, D. J Nutt 01/02/2010

        Article 

      3. A tale of two E-s - D. J. Nutt 20/09/2005

        Article 

      4. Polysubstance use: diagnostic challenges, patterns of use and health - Jason P. Connor, Matthew J. Gullo, Angela White, Adrian B. Kelly 07/2014

        Article 

    2. Optional Reading 5 items
      1. Memory-related hippocampal functioning in ecstasy and amphetamine users - Benjamin Becker, Daniel Wagner, Philip Koester, Katja Bender 2013-2

        Article 

      2. Neural correlates of the LSD experience revealed by multimodal neuroimaging - Robin L. Carhart-Harris, Suresh Muthukumaraswamy, Leor Roseman, Mendel Kaelen 26/04/2016

        Article 

      3. Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers - G. J. H. Dumont, E. Wezenberg, M. M. G. J. Valkenberg, C. A. J. de Jong 2008-4

        Article 

      4. Dissecting components of reward: ‘liking’, ‘wanting’, and learning - Kent C Berridge, Terry E Robinson, J Wayne Aldridge 02/2009

        Article 

  5. Week 5: The cannabinoid system 7 items
    1. Core Reading 3 items
      1. Julien, R.M. (2011) A Primer of Drug Action 12th Ed.New York: Worth Publishers:Chapter 14 'Cannabinoid agonists and antagonists' p 479-509

         

         

         Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the brain and behaviour. Sunderland: Sinauer Associates. Chapter 14, p.401-424

    2. Optional Reading 4 items
      1. Cannabis use and neurocognitive functioning in a non-clinical sample of users - April D. Thames, Natalie Arbid, Philip Sayegh 05/2014

        Article 

  6. Week 7: Psychostimulants 9 items
    1. Core Reading 5 items
      1. Julien, R.M. (2011) A Primer of Drug Action 11th Ed.New York: Worth Publishers: Chapter 11 "Caffeine and Nicotine" p361-395, Chapter 12 section on amphetamines p414-422 

         

        Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the brain and behaviour. Sunderland: Sinauer Associates. Chapters 12 p362-370 and Chapter 13, p373-394.

    2. Optional Reading 4 items
      1. Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review - Dimitris Repantis, Peter Schlattmann, Oona Laisney, Isabella Heuser 09/2010

        Article 

      2. Neuroethical issues in cognitive enhancement - B. J. Sahakian, S. Morein-Zamir 01/02/2011

        Article 

  7. Week 8: Nicotine 12 items
    1. Core Reading 4 items
      1. Julien's primer of drug action - Claire D. Advokat, Joseph E. Comaty, Robert M. Julien 2014

        Book  Chapter 6: nicotine

      2. Psychopharmacology: drugs, the brain, and behavior - Jerrold S. Meyer, Linda F. Quenzer c2013

        Book  Chapter 13: Nicotine

      3. Understanding drugs and behaviour - Andrew Parrott 2004

        Book  Chapter 5: Nicotine and Cigarette Smoking

    2. Optional Reading 8 items
  8. Week 8: Schizophrenia and antipsychotics 9 items
    1. Core Reading 5 items
      1. Julien, R.M. (2011) A Primer of Drug Action 12th Ed. New York:Worth Publishers. Chapter 4 "Antipsychotic drugs: Major tranquillisers to thymic stabilizers" p 91-140

         

        Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the Brain and Behaviour. Massachusetts: Sinauer Associates. Chapter 20 'Schizophrenia: Antipsychotic drugs' p 575-606

      2. Schizophrenia - Jim van Os, Shitij Kapur 08/2009

        Article 

      3. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis - Stefan Leucht, Andrea Cipriani, Loukia Spineli, Dimitris Mavridis 09/2013

        Article  You are definitely not expected to understand the statistical techniques used in this paper! Please concentrate on the introduction, discussion and the graphs on pages 954 and 955

    2. Optional Reading 4 items
      1. A critical overview of animal models of psychiatric disorders: challenges and perspectives - Joao Vinicius Salgado, Guy Sandner 2013

        Article  Please note that this paper is listed as optional reading for the lectures on antipsychotics, antidepressants and anxiolytics as it is relevant to all of them.

      2. Psychopharmacology of the negative symptoms: Current status and prospects for progress - Michael C. Davis, William P. Horan, Stephen R. Marder 05/2014

        Article 

  9. Week 9: Depression and antidepressants 9 items
    1. Core Reading 5 items
      1. Julien, R.M. (2011) A Primer of Drug Action 12th Ed. Chapter 5 p141-196

         

        Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the Brain and Behaviour. Massachusetts: Sinauer Associates. Chapter 19, p543-569 (please note that we do not cover mood stabilizers or bipolar disorder on this module). 

      2. BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis - Maryna Polyakova, Katharina Stuke, Katharina Schuemberg, Karsten Mueller 03/2015

        Article 

      3. The neurobiology of depression and antidepressant action - Paul Willner, Jørgen Scheel-Krüger, Catherine Belzung 12/2013

        Article  This is an extremely comprehensive (and long!) review paper of the current state of knowledge of the neurobiology of depression and pharmacological treatments. The lecture will summarise some parts of this paper. You do not need to read all of it, just the sections that were covered in the lecture.

      4. A brief history of the development of antidepressant drugs: From monoamines to glutamate. By: Hillhouse, Todd M., Porter, Joseph H., Experimental and Clinical Psychopharmacology, 10641297, 20150201, Vol. 23, Issue 1

        Article  This paper provides a very useful overview of antidepressants drugs and the use of ketamine as an antidepressant. You do NOT need to read the sections called 'glutametergic systems and major depressive disorder' and 'other glutamatergic drugs for the treatment of major depressive disorder'.

    2. Optional Reading 4 items
      1. A critical overview of animal models of psychiatric disorders: challenges and perspectives - Joao Vinicius Salgado, Guy Sandner 2013

        Article  Please note that this paper is listed as optional reading for the lectures on antipsychotics, antidepressants and anxiolytics as it is relevant to all of them.

      2. Faster, better, stronger: Towards new antidepressant therapeutic strategies - Olivia F. O’Leary, Timothy G. Dinan, John F. Cryan 04/2015

        Article 

  10. Week 10: Anxiety and Anxiolytics 9 items
    1. Core Reading 4 items
      1. Julien, R.M. (2011) A Primer of Drug Action 12th Ed. New York:Worth Publishers. Chapter 7 p236-270.

         

        Meyer, J.S. and Quenzer, L.F. (2013) Psychopharmacology: Drugs, the Brain and Behaviour. Massachusetts: Sinauer Associates. Chapter 18 p509-540

      2. Pharmacological treatment of anxiety disorders: Current treatments and future directions - Frank J. Farach, Larry D. Pruitt, Janie J. Jun, Alissa B. Jerud 12/2012

        Article 

      3. Benzodiazepines: Risks and benefits. A reconsideration - David S Baldwin, Katherine Aitchison, Alan Bateson

        Article 

    2. Optional Reading 5 items
      1. A critical overview of animal models of psychiatric disorders: challenges and perspectives - Joao Vinicius Salgado, Guy Sandner 2013

        Article  Please note that this paper is listed as optional reading for the lectures on antipsychotics, antidepressants and anxiolytics as it is relevant to all of them.